Unleashing the potential of simvastatin to osteogenesis: A review role of simvastatin in bone formation

• Author Details:   
• Vanshika Agarwal ^*
• Gaurav Patri
• Shruti Kedia
• Srishti Agarwal

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Owing to the efficiency of several regenerative procedures, the demand for effective biomaterials for bone augmentation procedures has gained a surge. In light of this, the newer material must have improved osteogenic properties combining pros of autologous bone grafts and eliminating their cons. On search, various anabolic drugs (bisphosphonates, calcitonin and simvastatin) aimed at upregulating intrinsic bone growth factors has been introduced. Simvastatin, a lipid lowering agent has been reported to promote osteoblastic activity and inhibit osteoclastic activity via various biological pathways. Several animal studies have demonstrated the bone- promoting effect of simvastatin when applied topically. Simvastatin is shown to increase cancellous bone volume, bone formation rate, and cancellous bone compressive strength.

Keywords: Simvastatin, Regeneration, Bone formation, Topical, Osteogenesis.