Odontogenic keratocysts have retained an enigmatic nature since their emergence, with their multifocal occurrence in both jaws complicating diagnosis and management. While OKCs are frequently linked to syndromic conditions such as Nevoid Basal Cell Carcinoma Syndrome (NBCCS), their occurrence in non-syndromic patients is rare and demands a distinct clinical approach. This case series analyzes non-syndromic patients presenting with multifocal, multiple OKCs of maxilla and mandible, focusing on their clinical, radiological, and histopathological characteristics and its aggressive behaviour necessitating long-term follow-up.
Keywords: Non-syndromic OKCs, Multiple sites, Enucleation.