- Visibility 40 Views
- Downloads 21 Downloads
- Permissions
- DOI 10.18231/j.jooo.11292.1714266298
-
CrossMark
Verrucous hyperplasia with moderate oral epithelial dysplasia: A case report
- Author Details:
-
Qazi Saba
-
Akshay Rathore
-
Achom Uma
-
Sylvia Waikhom
Qazi Saba
Akshay Rathore
Achom Uma
Sylvia Waikhom
Objective: To present a case of verrucous hyperplasia (VH) with moderate epithelial dysplasia in a 52-year-old male, detailing clinical features, histopathological findings, and treatment.
Case Presentation: A 52-year-old male reported pain and a gradually enlarging lesion on the left buccal mucosa for six months. He had a prior history of bidi smoking and gutka consumption, though discontinued 3–4 years ago. Clinical examination revealed a corrugated, tender, whitish-pink mass on the left buccal mucosa with associated oral submucous fibrosis. Histopathology of the excised lesion confirmed VH with moderate dysplasia.
Results: The lesion was managed surgically with adjuvant topical therapy, including corticosteroids and Immunomodulator drugs. Follow-up indicated clinical improvement with no evidence of recurrence.
Conclusion: Early diagnosis and intervention in VH are essential to prevent progression to verrucous carcinoma. Histopathology remains crucial for differentiation from other potentially malignant lesions.
References
- Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and Maxillofacial Pathology. 3rd ed. Philadelphia: Saunders; 2008. pp. 388–97.
- Shear M, Pindborg JJ. Verrucous hyperplasia of the oral mucosa. Cancer. 1980;46(8):1855–62. https://doi.org/10.1002/1097-
[Google Scholar] 0142(19801015)46:8<1855::aid-cncr2820460825>3.0.co;2-#. - Wang YP, Chen HM, Kuo RC, Yu CH, Sun A, Liu BY, et al. Oral verrucous hyperplasia: histologic classification, prognosis, and clinical implications. J Oral Pathol Med. 2009;38(8):651–6. https://doi.org/10.1111/j.1600-0714.2009.00790.x
[Google Scholar] - Slootweg PJ, Müller H. Verrucous hyperplasia or verrucous carcinoma. An analysis of 27 patients. J Maxillofac Surg. 1983;11(1):13–9. https://doi.org/10.1016/s0301-0503(83)80006-x
[Google Scholar] - Hsue SS, Wang WC, Chen CH, Lin CC, Chen YK, Lin LM. Malignant transformation in 1458 patients with potentially malignant oral mucosal disorders: a follow-up study based in a Taiwanese hospital. J Oral Pathol Med. 2007;36(1):25–9. https://doi.org/10.1111/j.1600-0714.2006.00491.x
[Google Scholar] - Hansen LS, Olson JA, Silverman S Jr. Proliferative verrucous leukoplakia. A long-term study of thirty patients. Oral Surg Oral Med Oral Pathol . 1985;60(3):285 –98. https://doi.org/10.1016/0030-4220(85)90313-5
[Google Scholar] - Chen YK, Hsuen SS, Lin LM. Increased expression of inducible nitric oxide synthase for human oral submucous fibrosis, verrucous hyperplasia, and verrucous carcinoma. Int J Oral Maxillofac Surg. 2002;31(4):419–22. https://doi.org/10.1054/ijom.2002.0246
[Google Scholar] - Poh CF, Zhang L, Lam WL, Zhang X, An D, Chau C, et al. A high frequency of allelic loss in oral verrucous lesions may explain malignant risk. Lab Invest. 2001;81(4):629–34. https://doi.org/10.1038/labinvest.3780271
[Google Scholar] - Swaminathan U, Joshua E, Rao UK, Ranganathan K. Expression of p53 and Cyclin D1 in oral squamous cell carcinoma and normal mucosa: An Immunohistochemical study. J Oral Maxillofac Pathol. 2012;16(2):172–177. https://doi.org/10.4103/0973-029X.98451
[Google Scholar] - Kang CJ, Chang JT, Chen TM, Chen IH, Liao CT. Surgical treatment of oral verrucous carcinoma. Chang Gung Med J. 2003;26(11):807–