- Visibility 128 Views
- Downloads 109 Downloads
- Permissions
- DOI 10.18231/j.jooo.88283.1759126624
-
CrossMark
Unveiling the enigma: A case report of adenoid cystic carcinoma in the hard palate
- Author Details:
-
Savita S Shiragur *
-
Sahana Srinath
-
Suganya G
-
Akalya Purushothaman
-
Ninad V Chavan
Savita S Shiragur *
Akalya Purushothaman
Adenoid cystic carcinoma (ADCC) was initially documented in 1853 and later termed by Spies in 1930. Previously perceived as benign, its malignant characteristics were elucidated in 1943. ADCC commonly originates from salivary glands, particularly from the ductal cells and myoepithelial cells, with key molecular abnormalities involving MYB and NFIB gene translocations. Clinically, ADCC predominantly affects adults aged 40-60 years with a slight female predominance and commonly arises in minor salivary glands. It presents as a painless, gradually enlarging mass. Histopathologically, ADCC exhibits cribriform, tubular, and solid patterns, with the solid subtype often indicating a poorer prognosis, and perineural invasion being a hallmark. Diagnostic challenges include distinguishing ADCC from similar tumors like polymorphous adenocarcinoma and pleomorphic adenoma. Management involves surgical excision, radiation, and chemotherapy. Here we present a case report of adenoid cystic carcinoma involving the hard palate in a 70-year-old male patient with a review of relevant literature.
References
- Ammad Ud Din M, Shaikh H. Adenoid Cystic Cancer. [Updated 2023 Apr 14]. In: StatPearls [Internet]. StatPearls Publishing; 2024 Jan–. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557855/.
- Godge P, Sharma S, Yadav M. Adenoid cystic carcinoma of the parotid gland. Contemp Clin Dent. 2012;3(2):223–6. https://doi.org/10.4103/0976-237X.96838
[Google Scholar] - Jang S, Patel PN, Kimple RJ, McCulloch TM. Clinical outcomes and prognostic factors of adenoid cystic carcinoma of the head and neck. Anticancer Res. 2017;37(6):3045–52. https://doi.org/10.21873/anticanres.11659
[Google Scholar] - Huang M, Ma D, Sun K, Yu G, Guo C, Gao F. Factors influencing survival rate in adenoid cystic carcinoma of the salivary glands. Int J Oral Maxillofac Surg. 1997;26(6):435–9. https://doi.org/10.1016/s0901-5027(97)80008-2
[Google Scholar] - Singaraju M, Singaraju S, Patel S, Sharma S. Adenoid cystic carcinoma: a case report and review of literature. J Oral Maxillofac Pathol. 2022;26(Suppl 1):S26–9. https://doi.org/10.4103/jomfp.jomfp_458_20
[Google Scholar] - Jaber MA, Hassan M, Ingafou M, Elameen AM. Adenoid cystic carcinoma of the minor salivary glands: a systematic review and meta- analysis of clinical characteristics and management strategies. J Clin Med. 2024;13(1):267. https://doi.org/10.3390/jcm13010267
[Google Scholar] - Yaga US, Gollamudi N, Mengji AK, Besta R, Panta P, Prakash B, et al. Adenoid cystic carcinoma of the palate: case report and review of literature. Pan Afr Med J. 2016;24:106. https://doi.org/10.11604/pamj.2016.24.106.8596
[Google Scholar] - Dillon PM, Chakraborty S, Moskaluk CA, Joshi PJ, Thomas CY. Adenoid cystic carcinoma: a review of recent advances, molecular targets, and clinical trials. Head Neck. 2016;38(4):620–7. https://doi.org/10.1002/hed.23925
[Google Scholar] - Coca-Pelaz A, Rodrigo JP, Bradley PJ, Vander Poorten V, Triantafyllou A, Hunt JL, et al. Adenoid cystic carcinoma of the head and neck--An update. Oral Oncol. 2015;51(7):652–61. https://doi.org/10.1016/j.oraloncology.2015.04.005
[Google Scholar] - Jardim da Silva F, de Azevedo JC Jr, Ralph ACL, Pinheiro JJV, Freitas VM, Calcagno DQ. Salivary glands adenoid cystic carcinoma: a molecular profile update and potential implications. Front Oncol. 2023;13:1191218. https://doi.org/10.3389/fonc.2023.1191218
[Google Scholar] - Pushpanjali M, Sujata DN, Subramanyam SB, Jyothsna M. Adenoid cystic carcinoma: an unusual presentation. J Oral Maxillofac Pathol. 2014;18(2):286–90. https://doi.org/10.4103/0973-029X.140796
[Google Scholar]