Evaluation of tolonium chloride as an aid in diagnosis of dysplastic changes in oral mucosa among tobacco smokers

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Review Article

Author Details : Amit Jain, Arpana Shekhawat, Harshul Joshi, Divya Singh, Sneha Udhani*

Volume : 6, Issue : 3, Year : 2020

Article Page : 110-113

https://doi.org/10.18231/j.jooo.2020.025

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Abstract

Background & Objectives: To evaluate the clinical utility of Tolonium chloride as a diagnostic aid
amongst high-risk patients i.e. patients with tobacco smoking habit, to identify potential areas that might
proceed into cancer and which are not otherwise identified during clinical examination and thus guide to
select the biopsy site.
Materials and Methods: A total of 180 individuals were selected for the study, Out of these 180
individuals, 95 individuals showed areas of stain retention in their oral mucosa and these 95 individuals
constituted the study group. However, 62 individuals out of the study group were not willing to undergo
biopsy. Only the remaining 32 individuals volunteered to participate in the study, from these volunteers’
biopsy specimens were obtained involving both stained and unstained area. Which were considered
separately, making a total of 64 specimens.
Results: The results of the present study showed sensitivity and specificity of 56.34% and 50.56%
respectively for the Tolonium chloride mouth rinse to be used as a routine screening agent in detecting
premalignant areas in otherwise apparent normal oral mucosa in high-risk group of people. In this study
0.403 P value shows insignificant correlation between the histopathological evaluation of the stained and
the unstained areas.
Conclusion: Tolonium chloride rinse is more sensitive as compared to the clinical examination alone, in
detecting dysplastic changes in clinically apparent normal oral mucosa, among tobacco smokers. Tolonium
chloride vital staining cannot be used to delineate the biopsy margins. Tolonium chloride might be used
as a diagnostic tool in the biopsy site selection. The procedure cannot be performed on routine basis for
high-risk group of people.

Keywords: Tolonium chloride, Vital staining, Normal oral mucosa.

How to cite : Jain A , Shekhawat A, Joshi H , Singh D , Udhani S , Evaluation of tolonium chloride as an aid in diagnosis of dysplastic changes in oral mucosa among tobacco smokers. J Oral Med Oral Surg Oral Pathol Oral Radiol 2020;6(3):110-113

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