Congenital granular cell epulis – Unraveling the histogenesis

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Case Series

Author Details : Vaishali Anil Nandkhedkar*, Jyoti Dilip Bhavthankar, Mandakini Subhash Mandale, Jayanti Govind Humbe, Savita Prashant Wagh, Poonam Rajendra Zanwar

Volume : 9, Issue : 2, Year : 2023

Article Page : 91-94

https://doi.org/10.18231/j.jooo.2023.020

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Abstract

Congenital Granular cell epulis is a rare benign tumor of the newborn. It also known as granular cell tumor of the newborn or Neumann's tumor. It originates exclusively on the alveolar ridge, most commonly seen in maxillary anterior region, typically seen as a mass protruding out of the mouth, which may interfere with respiration or feeding. Despite its striking appearance, the lesion is ultimately benign. However, immediate surgical treatment is required if there is a risk of airway obstruction or feeding difficulties. Here, two cases were reported to reveal the histological findings and reassess the immunohistochemical characteristics that may hint towards the histogenesis of the congenital epulis. Histopathology of both masses composed of diffuse sheets and clusters of polygonal cells containing small round to oval nuclei and abundant coarsely granular cytoplasm. The immunoreactivity of the granular cell was examined by immunohistochemical markers such as S100 protein, CD68, CD1a and Neuron specific enolase (NSE). In the present case tumour cells were positive for NSE and CD68 and negative for S100 and CD1a. Although the exact nature of its histogenesis still remains a mystery.
 

Keywords: Congenital epulis, Granular cell, Histogenesis, Neumann's tumor.

How to cite : Nandkhedkar V A, Bhavthankar J D, Mandale M S, Humbe J G, Wagh S P, Zanwar P R, Congenital granular cell epulis – Unraveling the histogenesis. J Oral Med Oral Surg Oral Pathol Oral Radiol 2023;9(2):91-94

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