Artificial saliva plus beta-glucan for treatment of xerostomia in older adults: The clinical study of effectiveness and salivary total antioxidant capacity levels

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Original Article

Author Details : Pakawan Tanviruch, Surawut Pongsiriwet, Jitjiroj Ittichaicharoen, Kanyarat Korwanich, Kathawut Tachasuttirut*

Volume : 10, Issue : 2, Year : 2024

Article Page : 99-106

https://doi.org/10.18231/j.jooo.2024.018

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Abstract

Background: To evaluate the effectiveness of 2 artificial saliva formulations, sodium carboxymethylcellulose artificial saliva spray and sodium carboxymethylcellulose artificial saliva spray plus β-glucan.
Materials and Methods: This study was a double-blind randomized controlled trial and involved older adults with xerostomia. The xerostomia inventory score, clinical oral dryness score, oral moisture degree, unstimulated salivary flow rate, and salivary total antioxidant capacity were measured prior to and after treatment. The results were evaluated 4 weeks after taking both products.
Results: The study included 51 subjects in the control (n = 25) and BG (n = 26) groups. xerostomia inventory score and clinical oral dryness score were significantly lower in both groups after 4 weeks of treatment (p<0 p=0.048). p=0.004).> Conclusion: The clinical signs and symptoms of xerostomia were improved by both control and artificial BG saliva. BG improved oral moisture more than the control. Furthermore, BG was more likely to prevent a decrease in salivary total antioxidant capacity than was the control.
 

Keywords: Xerostomia, Artificial saliva, Beta-glucan, Oral moisture, Total antioxidant capacity.

How to cite : Tanviruch P, Pongsiriwet S, Ittichaicharoen J, Korwanich K, Tachasuttirut K, Artificial saliva plus beta-glucan for treatment of xerostomia in older adults: The clinical study of effectiveness and salivary total antioxidant capacity levels. J Oral Med Oral Surg Oral Pathol Oral Radiol 2024;10(2):99-106

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