Saliva as a sample for liquid biopsy: A review

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Review Article

Author Details : Anirban Das*, Simantini Bhattacharjee

Volume : 10, Issue : 4, Year : 2024

Article Page : 261-264

https://doi.org/10.18231/j.jooo.2024.051

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Abstract

This paper reviews the recent advancements in liquid biopsy, focusing on its potential application in oral squamous cell carcinoma. Liquid biopsy, a non-invasive technique, offers a promising alternative to traditional biopsy methods by analyzing circulating tumor cells, exosomes, and circulating tumor DNA in bodily fluids like blood and saliva.The study highlights the advantages of saliva as a liquid biopsy substrate, including its ease of collection, non-invasive nature, and the presence of valuable biomarkers. Several potential markers for OSCC detection in saliva are discussed, such as somatic mutations, viral DNA, microRNAs, and protein biomarkers.While liquid biopsy holds great promise, challenges remain in terms of sensitivity, specificity, and standardization of techniques. Further research is needed to develop more reliable and cost-effective methods for analysing these biomarkers and translating them into clinical practice. By overcoming these limitations, liquid biopsy can revolutionize the early detection, diagnosis, and monitoring of OSCC, leading to improved patient outcomes.
 

Keywords: Circulating tumor cells (CTCs), Circulating tumor DNA (ctDNA), Oral squamous cell carcinoma (OSCC), Salivary biomarkers, Next­ generation sequencing (NGS).

How to cite : Das A, Bhattacharjee S, Saliva as a sample for liquid biopsy: A review. J Oral Med Oral Surg Oral Pathol Oral Radiol 2024;10(4):261-264

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