Copper in oral submucous fibrosis: implications in clinical trial

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Review Article

Author Details : Arpita Rai

Volume : 3, Issue : 3, Year : 2017

Article Page : 169-171

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Abstract

Oral sub mucous fibrosis (OSMF) is a chronic, debilitating, potentially malignant disorder caused primarily due to areca nut chewing. Burning sensation of oral cavity and reduced mouth opening are the hallmark of this disease. The etiopathogenesis of this disorder remains unclear. Several trace elements have been implicated in the pathogenesis of OSMF. In this review, the role of copper in OSMF has been summarized emphasizing various molecular pathways affected by this trace element. Available literature regarding serum, salivary, cytological and tissue levels of copper in OSMF has been updated. Including serum copper levels as an outcome in clinical trials assessing medicinal interventions may prove an attractive concept.

Keywords: Copper, Serum copper, Oral submucous fibrosis, OSMF, OSF

How to cite : Rai A, Copper in oral submucous fibrosis: implications in clinical trial. J Oral Med Oral Surg Oral Pathol Oral Radiol 2017;3(3):169-171

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